|
Colorectal Neoplasms
|
0.340 |
GeneticVariation
|
group |
LHGDN |
A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer.
|
11751380 |
2001 |
|
Colorectal Neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study.
|
18267032 |
2008 |
|
Colorectal Neoplasms
|
0.340 |
GeneticVariation
|
group |
LHGDN |
ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study.
|
18267032 |
2008 |
|
Colorectal Neoplasms
|
0.340 |
GeneticVariation
|
group |
LHGDN |
Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome.
|
18085999 |
2007 |
|
Colorectal Neoplasms
|
0.340 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan.
|
15679883 |
2005 |
|
Skin Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations.
|
17050553 |
2007 |
|
Skin Neoplasms
|
0.330 |
GeneticVariation
|
group |
LHGDN |
XPD polymorphism and risk of subsequent cancer in individuals with nonmelanoma skin cancer.
|
15298945 |
2004 |
|
Skin Neoplasms
|
0.330 |
GeneticVariation
|
group |
BEFREE |
In humans, mutation of the XPB or XPD gene impairs NER, resulting in hyper-sensitivity to sunlight and greatly increased skin tumor formation.
|
9427533 |
1997 |
|
Skin Neoplasms
|
0.330 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire.
|
17687452 |
2007 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Association of XPD polymorphisms with prostate cancer in Taiwanese patients.
|
17695467 |
2007 |
|
Prostatic Neoplasms
|
0.310 |
GeneticVariation
|
group |
LHGDN |
Association of XPD polymorphisms with prostate cancer in Taiwanese patients.
|
17695467 |
2007 |
|
Skin Abnormalities
|
0.310 |
Biomarker
|
group |
CTD_human |
Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic-related skin lesions.
|
17470448 |
2007 |
|
Skin Abnormalities
|
0.310 |
GeneticVariation
|
group |
BEFREE |
Mutations in the XPD subunit of the transcription/DNA repair factor (TFIIH) give rise to trichothiodystrophy (TTD), a rare hereditary multisystem disorder with skin abnormalities.
|
23221806 |
2013 |
|
Dermatologic disorders
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Mutations in the DNA binding region of XPA were from patients with the more severe disease often associated with neurological complications, whereas mutations in the C-terminal end of the protein, which interacts with the TFIIH transcription factor, were from patients with milder skin disease only.
|
9671271 |
1998 |
|
Dermatologic disorders
|
0.310 |
Biomarker
|
group |
CTD_human |
Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations.
|
17050553 |
2007 |
|
Stomach Neoplasms
|
0.310 |
GeneticVariation
|
group |
LHGDN |
Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy.
|
17009404 |
2006 |
|
Stomach Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy.
|
17009404 |
2006 |
|
Occupational Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
[Association between polymorphisms of XPD gene and susceptibility to chronic benzene poisoning].
|
16889696 |
2006 |
|
Intellectual Disability
|
0.110 |
GeneticVariation
|
group |
BEFREE |
Besides XP, mutations in XPD can cause another seemingly unrelated syndrome, trichothiodystrophy (TTD), characterized by sulfur-deficient brittle hair, ichthyosis, and physical and mental retardation.
|
7629061 |
1995 |
|
Intellectual Disability
|
0.110 |
Biomarker
|
group |
HPO |
|
|
|
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The overall analysis suggested a significant association between the ERCC2 Asp312Asn polymorphism and cancer risk.
|
28489582 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together with the role of 19S subunits in transcriptional regulation, homology between S12 and eIF3 and TFIIH subunits, coelution with immunoproteasome subunits, and differential posttranslational modification and nuclear localization, these data suggest a differential nuclear function of modified and unmodified S12 in cancer.
|
15221960 |
2004 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found out decreased cancer risk in genotype combinations between female patients and healthy controls: XPD Lys/Lys+XPC Lys/Gln (OR = 0.45; p = 0.02), XPD Lys/Gln+XPC Lys/Lys (OR = 0.32; p = 0.005), XPD Lys/Gln+XPC Lys/Gln (OR = 0.48; p = 0.02).
|
23673479 |
2013 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
When the polymorphisms in XPD Asp312Asn and Lys751Gln were mutually adjusted, XPD Asp312Asn was not associated with increased risk of cancer.
|
14757194 |
2004 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
At conditional regression analysis, the Gln/Gln genotype in the XPD codon 751 showed the strongest association with both leukemic transformation (odds ratio [OR] = 4.9; 95% confidence interval [95% CI], 2.0-12) and development of nonmyeloid malignancies (OR = 4.2; 95% CI, 1.5-12).
|
22496165 |
2012 |